A recent study suggests that individuals who discontinue popular GLP-1 drugs like Mounjaro or Wegovy may regain shed pounds at a significantly accelerated pace than those who end traditional diet and exercise plans.
Published data in a major health publication points out that while obese people frequently drop about a fifth of their total mass while undergoing treatment, the weight returns at an estimated rate of nearly a kilo each month after stopping.
"Users buying such medications must be aware of the danger of quick rebound weight gain when the therapy is stopped," warns expert Dr. Susan Jebb.
Such speed of recovery suggests a return to original weight in about one and a half years.
Weighing Treatments
The research, which reviewed dozens of studies involving thousands of patients, compared the effects of GLP-1 agonists with older methods.
Scientists note that people who shed pounds through lifestyle changes alone usually have a more gradual creep back—perhaps 0.1 kg a month—once they finish.
Explaining the Rapid Rebound
Experts suggest the mode of action of the drugs explains the heightened regain.
These medications imitate a body's own chemical called GLP-1, which controls appetite.
"Sustained high doses of the hormone levels several times higher than normal might result in the system to produce less of its own natural hormone, and could lessen responsiveness to its actions," explained Dr. Adam Collins, a nutrition expert.
"Discontinuation of this hormone supplement leads to appetite is no longer kept in check, making binge eating far more likely."
A Chronic Issue?
Health authorities suggest the injections for individuals with obesity-related medical conditions, accompanied by prescribed lifestyle changes.
Professionals say that, considering the significant potential of relapse, the therapy might need to be life-long.
This opinion is reinforced by drug manufacturers, who note that the findings "emphasize the chronic nature of obesity," akin to managing conditions like hypertension.
User Testimonies
Users who have stopped the medication report a sudden return of appetite.
"I experienced a trigger flipping and you're instantly starving," recalled an individual.
The struggle is worsened if individuals have not established lasting lifestyle or habit changes during therapy.
Widespread Use
Figures indicate that millions of people in the UK have tried weight-loss jabs in the past year, with demand continuing to grow.
- Use is greater among women than males.
- The middle-aged demographic shows the greatest usage rates.
- A large proportion obtain the drugs through private healthcare rather than the NHS.
In conclusion, researchers emphasize that while GLP-1 drugs are powerful tools for shedding pounds, they are not a permanent solution and long-term success likely depends on ongoing lifestyle management.
